Canakinumab for Residual Inflammatory Risk
نویسندگان
چکیده
منابع مشابه
Anti-inflammatory therapy with canakinumab for atherosclerotic disease: lessons from the CANTOS trial.
BACKGROUND Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with pre...
متن کاملGetting inflamed about canakinumab for CVD
canakinumab for CVD In the good old days, human beings went around in a state of semipermanent inflammation from parasites and infections, ate when they could, starved when they couldn’t, and rarely sat down. Few lived long enough to develop atherosclerosis. But in sedentary, well fed modern people who live beyond 60, inflammation has come to be feared as a cardiovascular risk factor. In a much...
متن کاملCanakinumab investigated for treating familial Mediterranean fever.
INTRODUCTION Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory syndrome. The treatment of choice is colchicine. However, ~40% of patients are only partial responders and 5-10% are non-responders. Advances in the understanding of the role of pyrin in the regulation of interleukin (IL)-1β activation has led to use of anti-IL-1 agents for colchicine-resistant FMF. ...
متن کاملCanakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome
OBJECTIVE To explore whether gene expression profiling can identify a molecular mechanism for the clinical benefit of canakinumab treatment in patents with tumour necrosis factor receptor-associated periodic syndrome (TRAPS). METHODS Blood samples were collected from 20 patients with active TRAPS who received canakinumab 150 mg every 4 weeks for 4 months in an open-label proof-of-concept phas...
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the aim of this study was to investigate the effect of inflammatory pulpal pain on spatial learning and memory in male wistar rats. fifty-six adult rats were divided into eight groups as follows (n=7 per group): control, sham-operated group that received normal saline, sham vehicle group that received vehicle of capsaicin, three capsaicin treated groups that received intradental injection of 10...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2017
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehx723